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The NGS Automation Market is expected to grow at a CAGR of 13.4% from 2022–2029 to reach $1.33 billion by 2029.
Next-Generation Sequencing (NGS) is an advanced genome sequencing technology primarily used for research and clinical diagnostics. It accurately determines the nucleotide sequence within entire genomes or specific DNA and RNA regions. NGS has become integral to various clinical applications, including disease diagnosis, prognosis, therapeutic decision-making, and patient follow-up. Moreover, its capability for massive parallel sequencing opens new avenues for personalized precision medicine.
The advent of NGS technology has led to a dramatic reduction in DNA sequencing costs, making it accessible to researchers worldwide. The NGS process involves several critical steps: sample pre-processing, library preparation, sequencing, and bioinformatics analysis. Among these, library preparation is particularly vital but remains time-consuming and repetitive, despite ongoing advancements in high-throughput sequencing techniques. This step involves multiple repetitive actions that require precise pipetting of small volumes, making it susceptible to manual errors that can compromise the entire NGS workflow. Automating the library preparation process can enhance efficiency, produce more consistent results, and improve laboratory productivity. Furthermore, NGS automation helps maintain turnaround times and boosts sample throughput.
In the initial stage of the standard NGS workflow, nucleic acids are extracted from the sample. During library preparation, DNA and RNA are prepared for processing and sequencing. This generally involves nucleic acid fragmentation, adapter ligation, and library quantitation, although additional steps may vary across different workflows. The prepared libraries are then loaded onto a flow cell and placed into the sequencer, where massive parallel sequencing occurs, enabling simultaneous analysis of all DNA segments. The resulting sequence data is analyzed using bioinformatics software.
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Manual workflows in NGS library preparation face several challenges. The numerous repetitive steps requiring precise pipetting of small volumes increase the likelihood of errors, even among skilled technicians. Such manual procedures also pose risks of contamination and variability. For example, the manual Illumina TruSeq Nano workflow entails ten distinct steps to attach adapters and barcodes to nucleotides, with bead-based purification processes particularly prone to error due to manual handling of magnets and magnetic particles.
Automating NGS library preparation offers significant benefits, including improved library quality and consistent yields, which lead to reliable and reproducible NGS data generation. Automation also enhances operational efficiency and reduces costs while minimizing contamination risks by limiting manual handling of reagents and samples. Consequently, the growing demand for automation in NGS workflows is anticipated to fuel the NGS automation market.
Additionally, one of the primary applications of NGS is in the drug discovery process within pharmaceutical and biotechnology firms. As R&D expenditures rise in these sectors, the adoption of NGS automation is expected to accelerate. Pharmaceutical companies prioritize research and development as a critical component of drug development, while the biotechnology industry is poised for significant growth due to increased investments in R&D to meet the rising demand for innovative medical solutions. The importance of R&D is underscored by the increasing number of drug approvals; for example, in 2020, the FDA’s Center for Drug Evaluation and Research (CDER) approved 53 novel drugs, up from 48 in 2019. High levels of R&D investment in the pharmaceutical and biotechnology sectors are projected to drive growth in the NGS automation market due to its vital role in drug discovery.
According to Meticulous Research®, the NGS automation market is expected to grow at a compound annual growth rate (CAGR) of 13.4%, reaching $940.2 million by 2029.
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Scope of the Report:
NGS Automation Market—by Product
- Workstation/Robotic Platform
- Reagents & Consumables
NGS Automation Market—by Application
- Drug Discovery
- Clinical Diagnostics
- Oncology
- Infectious Diseases
- Reproductive Health
- Other Clinical Diagnostics
- Other Applications
NGS Automation Market—by Sequencing Type
- Whole Genome Sequencing
- Whole Exome Sequencing
- Targeted Genome Sequencing
- Others
NGS Automation Market—by End User
- Hospitals & Diagnostic Laboratories
- Pharmaceutical And Biotechnology Companies
- Academic Research Institutes
- Others End Users
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